Generic Priligy Online (Dapoxetine) is a medication used for premature ejaculation treatment in male patients. Its “generic” name is Dapoxetine. It is one of the selective serotonin reuptake inhibitor (SSRI) medications. This drug is renowned for its quickness and efficiency when it comes to the PE treatment.


This medication was first devised by Eli Lilly pharmaceutics company as an antidepressant. As luck would have it, Priligy was not effective as a pill that treats depression. It was abandoned for a few years before being developed into an anti-PE medication. In the year of 2003, Eli Lilly sold the patent to Johnson & Johnson.
In 2005, two years after the deal, this medication was finally approved by the FDA. Nowadays, this medication is available in over fifty different countries, including Mexico, Spain, South Korea, Germany, Russia, Uruguay, and Argentina.


Curiously enough, this drug’s exact MOA is still uncertain. The most common theory is that it works by suppressing sodium-dependent serotonin transporter, therefore, boosting serotonin’s impact on the body.


Not every medication is suitable for you. You need to undergo a complete medical evaluation before committing to any sort of treatment, including the Priligy therapy. You must not use this medication if you have:

  • History of wooziness caused by low BP.
  • Cardiovascular system issues.
  • Depression.
  • Bleeding disorders.
  • Suicidal thoughts.
  • Phycological illnesses, including bipolar disorder and schizophrenia.
  • History of seizure diseases/epilepsy.
  • Underlying/current/previous issues with your kidneys and/or your liver.
  • Eye issues, especially ocular hypertension.

The above list is not 100% exhaustive. You need to get in touch with your MD before you start this treatment. Never begin any kind of therapy if your MD told you not to.


Your starting dosage depends heavily on your age, overall well-being level, your diet and many other factors. If we are talking averages, the usual starting dose is 30 milligrams. It may be altered by your MD – it can either be upped to 60 milligrams or lowered, all based on your body’s response to the therapy.

How to Take

In order to figure out how to take this medication, you must refer to the info provided by your MD and to the info printed out by the manufacturer.

Usually, this medication is taken 60 to 180 minutes before engaging in any kind of sexual activity.You must never take this pill more than 1 time in the span of 24 hours. The drug was not created/meant for everyday usage, so you must only take it “as needed”.

How Long Does It Last

This medication gets rapidly absorbed into the body, it only takes up to 120 minutes. Initial half-life is approximately 78 minutes for the 30-milligram dosage and 84 minutes for the 60-milligram dosage. The biological half-life is 1116 minutes for the 30-milligram dosage and 1320 minutes for the 60-milligram dosage.


There have been many clinical trials when it comes to this drug and its unwanted secondary responses. Most prevalent ones were nausea, vertigo, headache, diarrhoea, insomnia, and fatigue. The most common responses that lead patients to stop this treatment were nausea (2.2%) and vertigo (1.2%). Let’s split the unwanted responses into different categories:

Psychological: common (≥1/100–<1/10) – nervousness, restlessness, odd dreams, lower libido; uncommon (≥1/1000–<1/100) – depressive mood, mood swings, euphoria, anxiousness, lack of interest in everything, indifference, confused consciousness, disorientation, disorganized thoughts, exaggerated vigilance, sleep cycle disruption, sleep-onset insomnia, maintenance insomnia, nightmares, teeth grinding, complete loss of libido, anorgasmy.

Nervous system: very common (≥1/10) – vertigo, headache; common (≥1/100–<1/10) – sleepiness, less sharp focus, tremors, paraesthesia; uncommon (≥1/1000–<1/100) – fainting, acathisia, parageusia, hypersomnolence, lethargy, depression of consciousness; rare (≥1/10000–<1/1000) – physical activity-induced vertigo, sudden sleepiness.

Visual organs: common (≥1/100–<1/10) – blurry vision; uncommon (≥1/1000–<1/100) – corectasia and vision impairment.

Hearing: common (≥1/100–<1/10) – ringing.

Cardiovascular system: common (≥1/100–<1/10) – flushing; uncommon (≥1/1000–<1/100) – sinus pause, sinus bradycardia, pyknosphygmia, lowered BP, systolic hypertension; rare (≥1/10000–<1/1000) – sudden feeling of warmth.

Respiratory system: common (≥1/100–<1/10) – nasal congestion, yawning.

Gastroenteric tract: very common (≥1/10) – nausea; common (≥1/100–<1/10) – diarrhoea, constipation, stomachache, dyspepsia, bloating, dry mouth.

Skin and hypodermis: common (≥1/100–<1/10) – hyperhidrosis; uncommon (≥1/1000–<1/100) – itch, cold sweat.

Reproductive system: common (≥1/100–<1/10) – impotence; uncommon (≥1/1000–<1/100) – inability to ejaculate, anorgasmy.

Overall health: common (≥1/100–<1/10) – weariness, irascibility; uncommon (≥1/1000–<1/100) – asthenia, feeling intoxicated. It’s also worth pointing out that there are some withdrawal symptoms when it comes to the Priligy treatment. These include: dysphoria, agitation, irritability, vertigo, sensory issues (including paresthesia), cephalalgia, lethargy, rapid, often exaggerated changes in mood, sleeplessness, and hypomania. It must be noted that these symptoms occurred in patients that were taking this drug for >60 days straight and quit cold turkey, without properly lowering the dosage.

The above list is not 100% comprehensive. If you happen to experience any of the aforementioned symptoms or something out of the ordinary, you must immediately get in touch with your physician.


There are some warning signs of an overdose. You must immediately contact your nearest healthcare center/call 911 in case you:

  • Experience convulsions;
  • Experience severe vertigo and syncopal state;
  • Noticed any sudden mood swings;
  • Experience hyperhidrosis;
  • Have severe fever;
  • Experience a severe version of any symptoms mentioned in the side-effects list.
  • The research shows that taking 240 mg. of Priligy in a single day doesn’t cause unwanted secondary responses or overdoses.
  • Just to reiterate, if you suspect there’s been an overdose, do not hesitate to contact medical specialists. You will require urgent medical attention.


Some medications are known to interact with each other, possibly disrupting the intended effects, slowing them down or increasing your risks of encountering an adverse reaction. Here’s the incomplete list of medications that interact with this tablet:

  1. Alpha-blockers, including prazosin, indoramin, doxazosin, terazosin, alfuzosin, tamsulosin.
  2. Nitrates (medications used for angina treatment), including isosorbide, nitroglycerin.
  3. Antifungal agents, including ketoconazole, voriconazole, saquinavir, nefazodone, erythromycin, diltiazem, fluconazole, verapamil, cimetidine, ranitidine, roxithromycin, fluvoxamine, among many others.
  4. AIDS treatments, including amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, efavirenz, and nevirapine.
  5. Anti-ED medications, including Cialis and Viagra.
  6. Antidepressants, especially fluoxetine, fluvoxamine, vortioxetine, agomelatine, desvenlafaxine, duloxetine, venlafaxine, mianserin, mirtazapine, reboxetine, amitriptyline, imipramine, nortriptyline, doxepin, dothiepin.
  7. Macrolide antibiotics, including erythromycin, clarithromycin, azithromycin, telithromycin, roxithromycin.
  8. Opioid analgesics, including codeine, dihydrocodeine, and tramadol.
  9. H2RA medications, including cimetidine, omeprazole, famotidine, and ranitidine.
  10. Medications for hypertension, including ACE inhibitors, beta blockers, diuretics and so forth.

The above list is not 100% complete. You must get in touch with your physician before you commit to this treatment, you must write down an exhaustive list detailing all the health products you are currently using (including OTC medications, herbals, and prescription pills) and hand it to your MD.

Alcohol Interactions

There’s been enough clinical research data to suggest that you must avoid consuming liquor while undergoing this treatment. There is a possibility you might encounter unwanted side-effects, including lightheadedness, giddiness, exhaustion, constant tiredness, sleepiness, and decreased consciousness.

There is also enough data to suggest that drinking in moderation is okay. However, you must be mindful of the fact that even small doses of liquor may disrupt this drug’s effects and lead to a disappointing outcome, performance-wise. All in all, you’re better off not drinking at all.

Food Interactions

There are none. Even fatty foods don’t affect this drug’s absorption, i.e. don’t slow down its positive impact.

How to Improve This Drug’s Effectiveness

Man Exercising
Make some lifestyle adjustments

Even though this medication is well-known for its effectiveness when it comes to curing PE, you can still make some lifestyle adjustments that will definitely improve the effectiveness of this drug and help you eradicate PE completely. These are the lifestyle changes you can make in order to improve your overall health:

  • Quit smoking;
  • Curb your alcohol intake;
  • Remove stress from your life;
  • Maintain a healthy diet;
  • Find a suitable exercise regimen;
  • Lose weight.

These changes are never easy, but if you manage to make a few small steps towards the right direction, they will yield amazing results. There are many patient testimonies that show that this medication alone was enough to give a significant confidence boost that was required in order to finally make much-needed changes. Other testimonies note this medication, in combination with more natural techniques of sexual stamina improvement, was incredibly effective.

Miscellaneous Information

  • Chemical formula: C21H23NO.
  • This drug was meant to be swallowed as a whole, it was not meant for crushing and/or chewing.
  • There are no downsides/severe consequences if you happen to miss a dose, because this drug is only taken as needed.
  • You should drive and/or operate heavy machinery while taking this medication. Many patients report feeling dizzy and lightheaded.
Todd photo

It seems like I have found the perfect cure for my PE problem. Priligy just works. I can last up to twenty minutes and that’s more than I could ask for. By the way, I want to thank all the people that were openly talking about this drug. Reading you describe its effectiveness really helped me to muster up the courage and just try it. I have never been happier with the results. My sex life is back on track and that is the only thing I actually care about. There are minor side-effects, but who cares, right?

Rhett userpic

Here goes my personal experience. I did struggle with finding the right dose at first, but after a few failed attempts, I was finally able to find the perfect one. Honestly, my doctor was kind of lazy when it comes to my issue, but that’s neither here nor there. What can I say? With the right dosage, there was a huge improvement. I was barely able to last 2 minutes – now I can easily perform up to 10 minutes. My confidence was significantly boosted by this whole experience, gotta tell ya.

Stephen userpic

Started out with a low dosage, worked my way up to 60 milligrams. Now I can last up to 30 minutes. That’s more like it! Priligy was the perfect solution to my humiliating problem. I mean, I took some time for me to work up the courage to actually go to the doctor’s with this issue. I was so mortified by the mere thought of sharing this with someone… If someone is reading this – my advice, do not be afraid. You’re not alone in this. There’s shameful about requiring extra help once in a while.

Dean userpic

There’s only one real downside to Priligy, I don’t see many people talking about it. The need to plan sex, it kind of kills the whole spontaneity of it. Well, it could’ve been worse, y’know? It could’ve been ineffective. My experience with this drug is/was mostly positive. Planning for sex is incredibly annoying and mentally taxing, but, hey, at least I can last up to 20 minutes with no rubber on. I have been struggling with PE for the better part of my life and I’m honestly happy to say that something actually works.